Computational Biologist Positions


Up to two postdoctoral positions are available immediately. Salary will comply with National Institutes of Health standards, based on experience.
Successful applicants will participate in exciting research projects including but not limited to:
(1) Vaccine design: next-generation sequencing analysis will be used to understand the mechanism of antibody maturation, to identify broadly neutralizing antibodies, and to optimize antibody functions. Computational tools will be employed to analyze antibody-antigen complexesand to design novel probes and immunogens.

(2) Structure-function study of molecular complexes: computational tools will be developed to incorporate experimental data obtained from various experimental techniques, for example cryo-electron microscopy (cryo-EM), to understand structure-function relationship of large molecular assemblies such as enzyme complexes, transporters and ion channels; (3) Optogenetics: novel strategies will be developed to design and engineer optical proteins to control the function of critical components involved in signaling pathways and circuits implicated in neurodegenerative diseases. Successful applicants will have the opportunity to work with multiple experimental groups at TSRI (for vaccine design: and; for other research areas: and elsewhere.

We are seeking candidates with recently earned PhDs in computational biology, broadly defined. Preference will be given to those who have experience in development and application of computational methodologies associated with (1) Next-generation sequencing analysis; (2) Mathematical modeling of evolution and phylogeny; (3) Protein structure prediction, modeling and design; (4) Physical simulation of biomolecules. Proficiency in programming languages such as Fortran90, C++, Python and Perl is a must.

The Scripps Research Institute (TSRI) California Campus is located in La Jolla, the outskirt of San Diego and a beautiful resort area in California. With UCSD, Salk and other top research institutions in close proximity, TSRI offers a vibrant and nurturing environment for young researchers to pursue their scientific careers. To learn more about our research, please visit our web page at Interested applicants should send a recent CV and two to three letters of reference to Dr. Jiang Zhu (email:

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