We are seeking for highly motivated graduate students and postdocs for our lab, at the Weizmann institute of Science, Israel. Our lab studies the interplay between circadian clocks and metabolism. Our physiology and behavior are subject to daily oscillations that are driven by an endogenous circadian clock. The mammalian circadian timing system is composed of a central pacemaker in the brain that is entrained by daily light-dark cycles and in turn synchronizes subsidiary oscillators in virtually all cells of the body. The core clock molecular circuitry is based on interlocked negative transcription-translation feedback loops that generate daily oscillations of gene expression in cultured cells and living animals.Circadian clocks play a major role in orchestrating daily metabolism and their disruption can lead to metabolic diseases such as diabetes and obesity. Concomitantly, clocks are tightly coupled to cellular metabolism and respond to feeding cycles.
Our overarching goal is to identify daily metabolic cycles in mammals and mechanistically address their interplay with circadian clocks. We employ a diverse arsenal of experimental approaches ranging from biochemical and molecular biology methods through in vivo imaging in cultured cells and living animals to metabolomics analysis and animal behavioral studies.
Funding opportunities are available for graduate students and post docs as part of the Human Frontiers Science Program (HFSP) and the European Research Council (ERC) grants.
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