Post-doctoral position in yeast genomics, at the Université Pierre et Marie Curie (UPMC) ­CNRS, 75006 Paris, FRANCE

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A CNRS-funded position in bioinformatics is available for two years, to be filled before December 2010. The post-doctoral fellow will join an interdisciplinary laboratory gathering biologists, mathematicians, physicists and computer scientists around the unifying theme of microorganism genomics.

This position is part of a large collaborative project funded by the ANR, which relies on a unique combination of comparative, functional and population genomics to comprehensively describe, both at the inter- and intra-specific levels, an entire eukaryotic clade,. The objective is to nravel the molecular mechanisms driving the evolution of major cellular processes such as replication, recombination, phenotypic diversification and genome dynamics, through the study of a poorly explored monophyletic group of yeasts. This clade offers an outstanding compromise between a broad evolutionary range, a good conservation of genome organization and major heterogeneities in GC-content. This unique combination associated with a remarkable experimental flexibility will provide the opportunity to decipher
the molecular bases of major evolutionary changes, both at the structural and at the functional levels.The post-doctoral fellow’s main project will be to explore the mechanisms of genome evolution through the combined analysis of large data sets issued from whole genome sequencing and resequencing data, ancestral genome reconstruction and genome-wide replication/recombination patterns. This work will permit to answer long-standing questions about the interplay between replication/recombination and the dynamics of chromosome structure, gene
birth, mutation rate and GC-content in eukaryotic genomes.

The post-doctoral fellow should be qualified in data analysis, programming and statistics. A good experience in genomics is required. We are looking for highly motivated candidates who have an interest for fundamental biological questions related to genome evolution.

Contact: gilles.fischer_at_upmc.fr

Further information about the host laboratory can be found at:

http://www.upmc.fr/fr/recherche/pole_4/pole_vie_et_sante/genomique_des_microorganismes_fre_3214.html

tel: +33 (0)1 44 27 81 39

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